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Mps-BAY 2a

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SI-4112

Mps-BAY 2a, >98% (HPLC)

CAS No. : [1382477-96-4]

MDL No. : MFCD29081183

Synonyms : N-Cyclopropyl-4-(8-(isobutylamino)-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl)benzamide

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Chemical Properites
Mol. Formula :
C29H28N6O
Mol. Weight :
476.57
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : A potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.

References : Liu Y. et al.: J. Med. Chem., 58(8), 3366-3392, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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