MRK-016

SI-7079

MRK-016, >98% (HPLC)

CAS No. : [342652-67-9]

IUPAC Name : 3-(3-(tert-Butyl)-2-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)pyrazolo[1,5-d][1,2,4]triazin-7-yl)-5-methylisoxazole

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MRK‑016 selectively targets α5‑containing GABAA receptors, acting as an inverse agonist with an EC₅₀ of 3 nM and subnanomolar affinities for major benzodiazepine‑sensitive receptor subtypes. Its strong CNS penetration and α5 preference make it a valuable tool for probing hippocampal inhibition and cognition‑related pathways.

References : Chambers M. S. et al.: J. Med. Chem., 47(24), 5829-32, 2004; Atack J.R. et al.: J. Pharmacol. Exp. Ther., 331(2), 470-84, 2009; Eimerbrink M. J. et al.: Behav. Brain Res., 288, 50-3, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.