MRT-67307

SI-7496

MRT-67307, >98% (HPLC)

CAS No. : [1190378-57-4]

IUPAC Name : N-(3-((5-Cyclopropyl-2-((3-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MRT-67307 inhibits IKKε (IC₅₀= 160 nM) and TBK1 (IC₅₀= 19 nM) and also suppresses ULK1 and ULK2 with low‑nanomolar potency. By targeting these autophagy‑ and immune‑regulatory kinases, MRT-67307 robustly blocks autophagy in cells, making it a valuable tool for studying innate‑immune signaling and autophagy control.

References : Clark K. et al.: Biochem. J. 434(1), 93-104, 2011; Petherick K. J. et al.: J. Biol. Chem., 290(18), 11376-83, 2015; Zhu Z. et al.: Cancer Discov., 4(4), 452-65, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.