MRT-68921 hydrochloride

SI-7754

MRT-68921 hydrochloride, >98% (HPLC)

CAS No. : [2070014-87-6]

IUPAC Name : N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide hydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MRT-68921 hydrochloride potently inhibits NUAK1 and ULK1/2 (IC₅₀ = 2.9 nM and 1.1 nM) and blocks autophagy, leading to oxidative‑stress imbalance, ROS generation, apoptosis, and reduced tumor‑cell growth. Its combined effects make it a valuable tool compound for studying autophagy‑regulated survival pathways in cancer models such as breast cancer.

References : Petherick K. J. et al.: J. Biol. Chem., 290(18), 11376-83, 2015; Chen Y. et al.: Cell Death Dis.,11(8), 712, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.