MS-453

SI-6658

MS-453, >98% (HPLC)

CAS No. : [2059892-29-2]

IUPAC Name : N-(3-((6,7-Dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : MS-453 selectively inhibits SETD8 with sub‑micromolar potency (IC₅₀= 804 nM) through covalent modification of a nearby cysteine residue. It is selective against 28 other methyltransferases, and crystallographic analysis defines its binding mode, supporting its use in designing high‑quality SETD8 probes.

References : Butler. K. V. et al.: J. Med. Chem., 59(21), 9881-9889, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.