MS-645

SI-6443

MS-645, >98% (HPLC)

CAS No. : [2250091-96-2]

IUPAC Name : N,N'-(Decane-1,10-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide)

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : MS-645 targets BRD4 through bivalent engagement of BD1 and BD2 (K_i = 18.4 nM), stabilizing a dual‑domain inhibitory conformation that leads to prolonged suppression of BRD4‑regulated transcriptional programs in solid‑tumor cells.

References : Ren C. et al.: Proc. Natl. Acad. Sci. U S A., 115(31), 7949-7954, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.