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MSA-2 dimer

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SI-6958

MSA-2 dimer, >98% (HPLC)

CAS No. : [2377881-92-8]

IUPAC Name : 4,4'-(Propane-1,3-diylbis(6-methoxybenzo[b]thiophene-5,2-diyl))bis(4-oxobutanoic acid)

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Chemical Properites
Mol. Formula :
C29H28O8S2
Mol. Weight :
568.66
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MSA‑2 dimer functions as a selective oral STING agonist, binding STING as a stable non‑covalent dimer (Kd = 145 µM). With superior permeability compared to cyclic dinucleotides, it induces robust and long‑term antitumor and immune‑activating effects.

References : Pan B. S. et al.: Science, 369(6506), eaba6098, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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