mTOR inhibitor

SI-8117

mTOR inhibitor, >98% (HPLC)

IUPAC Name : (S)-3-Methyl-4-(7-((R)-3-methylmorpholino)-2-(pyridin-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl)morpholine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a brain‑penetrant catalytic mTOR inhibitor emerging from SAR optimization to eliminate the genotoxicity risk observed in the earlier lead (compound 1). It effectively suppresses aberrant mTOR hyperactivity and improves survival in neuronal Tsc1‑knockout mouse models, demonstrating strong CNS‑target engagement. Although oral exposure in higher species is limited, compound 9 remains a valuable CNS tool molecule for probing mTOR‑driven neurobiology and disease mechanisms.

References : Bonazzi S. et al.: J. Med. Chem., 66(13), 9095-9119, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.