Murizatoclax

SI-7915

Murizatoclax, >98% (HPLC)

CAS No. : [2245848-05-7]

Synonyms : AMG-397

IUPAC Name : (1S,11'R,12'S,16'R,16a'R,18a'R,E)-6-Chloro-16'-methoxy-11',12'-dimethyl-16'-(((R)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)methyl)-3,4,12',13',16',16a',17',18',18a',19'-decahydro-1'H,2H,3'H,11'H-spiro[naphthalene-1,2'-[5,7]ethenocyclobuta[i][1,4]oxazepino[3,4-f][1]thia[2,7]diazacyclohexadecin]-8'(9'H)-one 10',10'-dioxide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Murizatoclax potently inhibits MCL‑1 with a K_i of 15 pM and binds competitively to the BH₃ pocket, antagonizing MCL‑1 interactions with pro‑apoptotic proteins. Its strong oral activity and target selectivity make it a valuable tool for investigating MCL‑1–driven tumor survival and therapeutic vulnerability.

References : Wang H. et al.: 14(1), 67, 2021; Caenepeel S. et al.: Cancer Res., 80,16 6218, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.