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N-Deacetyl colchicine

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SL-6536

N-Deacetyl colchicine, >98%

CAS No. : [3476-50-4]

IUPAC Name : (S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one

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Chemical Properites
Mol. Formula :
C20H23NO5
Mol. Weight :
357.41
Appearance :
Pale yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Colchicine and related analogs, which is a microtubule polymerization inhibitor, used to treat gout and behcet's disease.

References : Bonfoco E. et al.: Exp Cell Res., 218(1), 189-200,1995; Hastie S. B. Pharmacol Ther., 51(3), 377-401,1991; Otani K. et al.: Sci Rep., 6, 32587, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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