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N-Desethyl sunitinib-d5

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SL-388

N-Desethyl sunitinib-d5, >98% (CP)

Isotopic Purity : 98 atom % D

CAS No. : [1217247-62-5]

MDL No. : MFCD28343984

Related CAS No. : [356068-97-8] of the unlabelled compound

Synonyms : SU-12662-d5

IUPAC Name : (Z)-N-(2-((Ethyl-d5)amino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

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Chemical Properites
Mol. Formula :
C20H18D5FN4O2
Mol. Weight :
375.45
Appearance :
Yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : N-Desethyl sunitinib-d5 is the deuterium labelled analog of N-Desethyl sunitinib, a major metabolite formed during the metabolism of Sunitinib by cytochrome P450 (CYP) 3A4. The parent compound and active metabolite both have similar biochemical activity and potency and reach similar plasma concentrations.

References : Brett E. H.et.al.: Clinical Cancer Research, 15(7), 2497, 2009.; Adams V R.et.al.: Clin Ther., 29(7),1338, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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