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N-Desmethyl diltiazem

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N-Desmethyl diltiazem, >98%

CAS No. : [86408-45-9]

MDL No. : MFCD08063659

Synonyms : Dilitiazem EP impurity D

IUPAC Name : (2S,3S)-2-(4-Methoxyphenyl)-5-(2-(methylamino)ethyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate

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Chemical Properites
Mol. Formula :
C21H24N2O4S
Mol. Weight :
400.49
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Methanol
For Laboratory research use only, not for drug, household or other uses.

Applications : N-Desmethyl diltiazem is a metabolite of Diltiazem, which is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist). Diltiazem EP impurity D.

References : Kraus R. L. et al.: J. Biol Chem., 273(42), 27205-27212, 1998; Freitas F. et al.: Fundam Clin. Pharmacol., 29(1), 31-40, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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