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N-Desmethyl-N-nitroso netupitant

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N-Desmethyl-N-nitroso netupitant, >98%

IUPAC Name : 2-(3,5-Bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-nitrosopiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide

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5MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C29H29F6N5O2
Mol. Weight :
593.57
Appearance :
Pale brown solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Netupitant, which is a highly potent and selective, orally active neurokinin-1 receptor (NK-1) antagonist. This is used to prevent nausea and vomiting that is caused by cancer medicines.

References : Flick C. A et al.: Bioorg. Med. Chem. 24(9), 1937-1980, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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