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N,N,O-Tridesmethyl desacetyl diltiazem-d4

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SL-2080

N,N,O-Tridesmethyl desacetyl diltiazem-d4, >98% (CP)

Isotopic Purity : 98 atom % D

Related CAS No. : [115992-91-1] of the unlabelled compound

IUPAC Name : (2S,3S)-5-(2-Aminoethyl-d4)-3-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one

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Chemical Properites
Mol. Formula :
C17H14D4N2O3S
Mol. Weight :
334.43
Appearance :
Solid
Melting Point :
Nit available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled impurity and an intermediate in the preparation of Diltiazem, which is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).

References : Kraus R. L. et al.: J. Biol Chem., 273(42), 27205-27212, 1998; Freitas F. et al.: Fundam Clin. Pharmacol., 29(1), 31-40, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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