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N-Nitroso desisoproyl selexipag acid impurity

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N-Nitroso desisoproyl selexipag acid impurity, >98%

IUPAC Name : 2-(4-((5,6-Diphenylpyrazin-2-yl)(nitroso)amino)butoxy)acetic acid

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Chemical Properites
Mol. Formula :
C22H22N4O4
Mol. Weight :
406.44
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Selexipag, which is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor). Selexipag is used to treat pulmonary arterial hypertension (PAH).

References : Kuwano K. et al.: J. Pharmacol Exp Ther., 322(3), 1181-1188, 2007; Mous D. S. et al.: Am. J. Physiol Lung Cell Mol Physiol., May 10, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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