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N-Nitroso desmethyl diltiazem

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N-Nitroso desmethyl diltiazem, >98%

IUPAC Name : (2S,3S)-2-(4-Methoxyphenyl)-5-(2-(methyl(nitroso)amino)ethyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C21H23N3O5S
Mol. Weight :
429.49
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Diltiazem, which is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist). Diltiazem is used in many clinical scenarios as an antihypertensive, anti-arrhythmic, and anti-anginal.

References : Kraus R. L. et al.: J. Biol Chem., 273(42), 27205-27212, 1998; Freitas F. et al.: Fundam Clin. Pharmacol., 29(1), 31-40, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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