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N-Nitroso desmethyl tepotinib

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SL-10002

N-Nitroso desmethyl tepotinib, >98%

IUPAC Name : 3-(1-(3-(5-((1-Nitrosopiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile

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Back Order  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C28H25N7O3
Mol. Weight :
507.55
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Tepotinib, which is an orally active, highly selective, reversible ATP-competitive inhibitor of c-Met.Tepotinib effectively inhibits c-Met phosphorylation and promotes autophagy. Additionally, it has demonstrated antitumor activity.

References : Bladt F. et al.: Clin Cancer Res., 19(11), 2941-2951, 2013; Zhan N. et al.: Gene Expr., 18(2), 135-147, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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