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N-Nitroso levoleucovorin-2

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N-Nitroso levoleucovorin-2, >98%

IUPAC Name : (4-((((S)-2-Amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic acid

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5MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C20H22N8O8
Mol. Weight :
502.44
Appearance :
Pale beige solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Levoleucovorin, which is the pharmacologically active levoisomer of racemic Leucovorin. It can be used as a rescue agent following high-dose methotrexate therapy. Additionally, Levoleucovorin is used in combination with Fluorouracil for the treatment of advanced metastatic colorectal cancer.

References : Chuang V. T. et al.: Ann Pharmacother., 46(10), 1349-57, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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