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N-Nitroso N-desmethyl ponatinib

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SL-9800

N-Nitroso N-desmethyl ponatinib, >98%

IUPAC Name : 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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5MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C28H24F3N7O2
Mol. Weight :
547.54
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Ponatinib, which is a multi-targeted kinase inhibitor (TKI). Ponatinib is used to treat certain types of leukemia.

References : O'Hare T. et al.: Cancer Cell 16(5), 401-412, 2009; Gozgit J. M. et al.: Mol Cancer Ther., 10(6), 1028-1035, 2011; Uchida T. et al.: Exp Hematol., 42(5), 369-379, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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