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N-Nitroso N-desmethyl terbinafine

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N-Nitroso N-desmethyl terbinafine, >98%

IUPAC Name : (E)-N-(6,6-Dimethylhept-2-en-4-yn-1-yl)-N-(naphthalen-1-ylmethyl)nitrous amide

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5MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C20H22N2O
Mol. Weight :
306.41
Appearance :
Pale brown solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Terbinafin, which is an orally active and potent antifungal agent. Terbinafin is a non-competitive inhibitor of squalene epoxidase from Candida (Ki = 30 nM). It also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. This compound contains an Alkyne group and can act as a click chemistry reagent, undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

References : Ryder N. S. et al.: Br. J. Dermatol.,126 Suppl 39, 2-7, 1992; Mieth H. et al.: Clin Exp Dermatol.,14(2), 104-7, 1989.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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