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N-Nitroso N-methyl riociguat

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N-Nitroso N-methyl riociguat, >98%

Synonyms : Riociguat nitroso USP related compound C

IUPAC Name : Methyl (4-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-6-(methyl(nitroso)amino)pyrimidin-5-yl)(methyl)carbamate

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Chemical Properites
Mol. Formula :
C21H20FN9O3
Mol. Weight :
465.45
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Riociguat, which is an oral stimulator of soluble guanylate cyclase (sGC). It is used in the treatment of pulmonary hypertension.

References : Ding X. H. et al.: Bioorg. Med. Chem. 23(9), 1895-1922, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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