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N-Nitroso nadolol

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N-Nitroso nadolol, >98%

CAS No. : [134720-06-2]

IUPAC Name : N-(tert-Butyl)-N-(3-((6,7-dihydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)-2-hydroxypropyl)nitrous amide

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Chemical Properites
Mol. Formula :
C17H26N2O5
Mol. Weight :
338.40
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Nadolol, which is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research.

References : von Alvensleben J. C. et al.: Pediatr Cardiol., 38(3), 525-530, 2017; Abe O. et al. Eur J. Clin Pharmacol., 74(6), 775-783, 2018; Vegas O. et al.: Behav Brain Res., 205(1), 200-6, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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