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N-Nitroso nilotinib

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N-Nitroso nilotinib, >98%

CAS No. : [2925306-68-7]

Synonyms : N-Nitroso nilotinib impurity

IUPAC Name : 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

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Chemical Properites
Mol. Formula :
C28H21F3N8O2
Mol. Weight :
558.53
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Nilotinib, which is a selective Bcr-Abl tyrosine kinase inhibitor, for the potential treatment of various leukemias, including chronic myeloid leukemia (CML).

References : Weisberg E. et al. Blood, 109(5), 2112-2120, 2007; Liu Y. et al.: J. Hepatol, 55(3), 612-625, 2011; Hochhaus A. et al.: Cell Cycle, 10(2), 250-260, 2011; Ammoun S. et al.: Neuro Oncol., 13(7), 759-766, 2011; Rhee C. K. et al.: Respiration., 82(3), 273-287, 2011; Weisberg E. et al. Cancer Cell, 7(2), 129-141, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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