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N-Nitroso sotalol

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N-Nitroso sotalol, >98%

CAS No. : [134720-07-3]

IUPAC Name : N-(4-(1-Hydroxy-2-(isopropyl(nitroso)amino)ethyl)phenyl)methanesulfonamide

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Chemical Properites
Mol. Formula :
C12H19N3O4S
Mol. Weight :
301.36
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a nitrosamine impurity of Sotalol, which is an orally active, non-selective beta-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be utilized in the research of pediatric arrhythmias. Sotalol works by blocking beta-receptors and potassium KCNH2 channels. Additionally, Sotalol acts as an antiepileptic agent.

References : Reyes-Corral M. et al.: J. Pharmacol Exp. Ther., 369(1), 152-162, 2019; Xiaomei Li X. et al.: Pediatr Cardiol., 38(7), 1450-1455, 2017; Borowicz-Reutt K. K. et al. Pharmacol Rep., 73(2), 516-524, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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