N-Nitroso valsartan impurity 3

SL-9081

N-Nitroso valsartan impurity 3, >98%

CAS No. : [2407652-86-0]

IUPAC Name : N-((2'-Cyano-[1,1'-biphenyl]-4-yl)methyl)-N-nitroso-L-valine

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Applications : This is a nitrosamine impurity of Valsartan, which is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.

References : Shan H. et al.: J. Cell Mol Med., 18(6),1071-1080, 2014; Wang Y. et al.: Alcohol Clin Exp Res. 38(10), 2529-4250, 2014; Sui X. et al.: J. Cell Mol Med. 19(8), 1773-1782, 2015; Jiang Y. et al.: Cardiovasc Pathol. 24(4), 224-229, 2015; Ping G. et al.: Pharmacol Biochem Behav. 124, 5-12, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.