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N-Oxide impurity for nintedanib esylate CRS

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N-Oxide impurity for nintedanib esylate CRS, >98%

IUPAC Name : (Z)-1-(2-((4-(((6-Carboxy-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide

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Chemical Properites
Mol. Formula :
C30H31N5O6
Mol. Weight :
557.61
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
H2O
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Nintedanib, which is a multi-target tyrosine kinase inhibitor that works by competitively binding to the intracellular adenosine triphosphate (ATP) binding site on growth factor receptors, including vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and fibroblast growth factor receptors (FGFR). Nintedanib is used to treat idiopathic pulmonary fibrosis.

References : Flick C. A et al.: Bioorg. Med. Chem., 24(9), 1937-1980, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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