N14

SI-7352

N14, >98% (HPLC)

IUPAC Name : 4-((Dimethylamino)methyl)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)benzenesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : N14 is an optimized MCC950‑derived NLRP3 inflammasome inhibitor designed to replace the furan moiety associated with potential liver‑injury liabilities. It retains strong NLRP3 inhibitory potency (IC₅₀ = 25 nM) while showing markedly improved tolerability in human hepatic cell lines and mouse primary hepatocytes. N14 also exhibits excellent pharmacokinetics, including 85.2% oral bioavailability.

References : Li N. et al.: J. Med. Chem., 66(18), 12966-12989, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.