nAChR agonist 1

SI-5658

nAChR agonist 1, >98% (HPLC)

CAS No. : [1394371-75-5]

IUPAC Name : 4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : This is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. This can be develpoped for the treatment of Alzheimer’s disease.

References : Sinha N. et al.:J. Med Chem., 63(3), 944-960, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.