Narazaciclib

SI-7799

Narazaciclib, >98% (HPLC)

CAS No. : [1357470-29-1]

Synonyms : ON-123300

IUPAC Name : 8-Cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Narazaciclib potently inhibits CDK4, CDK6, Ark5, PDGFRβ, FGFR1, RET, and FYN at low‑nanomolar concentrations, reflecting its multi‑targeted kinase profile. As a brain‑penetrant agent, it suppresses Akt phosphorylation and activates Erk in a dose‑dependent manner in brain tumors, highlighting its relevance for CNS‑associated malignancies.

References : Zhang X. et al.: Mol. Cancer Ther., 13(5), 1105-16, 2014; Divakar S. K. et al.: Leukemia, 30(1), 86-93, 2016; Perumal D. et al.: Cancer Res., 76(5), 1225-36, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.