Nateglinide

SL-11115

Nateglinide, >98%

CAS No. : [105816-04-4]

Synonyms : Senaglinide; A4166

IUPAC Name : ((1r,4S)-4-Isopropylcyclohexane-1-carbonyl)-L-phenylalanine

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Applications : Nateglinide is an orally active, short-acting insulinotropic agent as well as a DPP IV inhibitor. Its mechanism of action involves the inhibition of ATP-sensitive potassium channels within pancreatic β-cells. Nateglinide is indicated for the management of type 2 (non-insulin-dependent) diabetes mellitus.

References : Christopher J. D. et al.: Drugs, 60(3), 6, 2000; Shiling H. et al.: European Journal of Pharmacology, 442, 163-171, 2002; Jian L. et al.: Metabolism, 62(1), 90-9, 2013; Duffy N. A. et al.: Eur. J. Pharmacol., 568(1-3), 278-86, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.