Navitoclax

SI-7916

Navitoclax, >98% (HPLC)

CAS No. : [923564-51-6]

Synonyms : ABT-263

IUPAC Name : (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Navitoclax potently inhibits multiple anti‑apoptotic BCL‑2 family members, including BCL‑xL, BCL‑2, and BCL‑w, with K_i values below 1 nM. Its strong oral activity and broad target engagement make it a key tool compound for investigating apoptosis and therapeutic vulnerabilities in cancer.

References : Lock R. et al.: Pediatr. Blood Cancer, 50(6), 1181-1189, 2008; Wong M. et al.: Mol. Cancer Ther., 11(4), 1026-1035, 2012; Chen J. et al.: Mol. Cancer Ther., 10(12), 2340-9, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.