Navitoclax dihydrochloride

SI-7919

Navitoclax dihydrochloride, >98% (HPLC)

CAS No. : [1093851-28-5]

Synonyms : ABT-263 dihydrochloride

IUPAC Name : (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide dihydrochloride

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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Navitoclax dihydrochloride potently targets the anti‑apoptotic BCL‑2 family members BCL‑xL, BCL‑2, and BCL‑w, exhibiting sub‑nanomolar binding affinity (K_i < 1 nM). Its strong oral activity and broad target engagement make it a key tool compound for investigating apoptosis regulation and cancer therapeutics.

References : Lock R. et al.: Pediatr. Blood Cancer, 50(6), 1181-9, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.