Navitoclax-piperazine

SI-7918

Navitoclax-piperazine, >98% (HPLC)

CAS No. : [2143096-93-7]

Synonyms : ABT-263-piperazine

IUPAC Name : (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((1-(phenylthio)-4-(piperazin-1-yl)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Navitoclax‑piperazine is a Navitoclax‑derived BCL‑xL inhibitor that acts as the target‑binding component of the PROTAC DT-2216. When coupled to a VHL E3 ligase ligand via a linker, it forms the heterobifunctional degrader DT-2216, enabling selective BCL‑xL degradation.

References : Khan S. et al.: Nat. Med., 25, 1938–1947, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.