Navtemadlin

SI-6489

Navtemadlin, >98% (HPLC)

CAS No. : [1352066-68-2]

Synonyms : AMG-232; KRT-232

IUPAC Name : 2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((R)-1-(isopropylsulfonyl)-4-methylpentan-3-yl)-3-methylpiperidin-3-yl)acetic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Navtemadlin disrupts the p53–MDM2 interaction with nanomolar potency (IC₅₀ = 0.6 nM) and binds MDM2 with very high affinity (K_D= 0.045 nM). As an orally active agent, it effectively reactivates p53 signaling in MDM2‑driven cancers.

References : Canon J. et al.: Mol Cancer Ther., 14(3), 649-58, 2015; Rew Y. et al.: J. Med. Chem., 57(15), 6332-41, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.