Navtemadlin-d7

SI-7474

Navtemadlin-d₇, >98% (HPLC)

Synonyms : AMG-232-d₇; KRT-232-d₇

IUPAC Name : 2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-3-methyl-1-((propan-2-yl-d₇)sulfonyl)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Navtemadlin‑d₇ is a deuterium‑labelled version of Navtemadlin, a nanomolar‑potency inhibitor of the p53–MDM2 interaction (IC₅₀= 0.6 nM) with sub‑nanomolar binding affinity for MDM2 (K_d = 0.045 nM). The labelleld analog is suitable for LC‑MS quantification and metabolic‑tracing studies.

References : Russak E. M. et al.: Ann. Pharmacother., 53(2), 211-216, 2019; Canon J. et al.: Mol. Cancer Ther., 14(3), 649-58, 2015; Rew Y. et al.: J. Med. Chem., 57(15), 6332-41, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.