NCATS-SM-5637

SI-6520

NCATS-SM-5637, >98% (HPLC)

CAS No. : [2170615-16-2]

Synonyms : NSC-791985

IUPAC Name : 1-(5-Chloro-2-ethylphenyl)-3-(4-(4-chlorophenyl)thiazol-2-yl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : NCATS‑SM5637 selectively targets mutant IDH1, inhibiting the R132H and R132C variants with IC₅₀ values of 81 nM and 72 nM. This specificity supports its use in probing IDH1 mutation–dependent metabolic and epigenetic pathways.

References : Rohde J. M. et al.: J. Med. Chem., 64(8), 4913-4946, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.