NCB-0846

SI-6921

NCB-0846, >98% (HPLC)

CAS No. : [1792999-26-8]

IUPAC Name : (1s,4s)-4-((2-((1H-Benzo[d]imidazol-6-yl)amino)quinazolin-8-yl)oxy)cyclohexan-1-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : NCB‑0846 selectively inhibits TNIK with strong potency (IC₅₀ = 21 nM), thereby suppressing Wnt‑driven transcriptional programs. It also interferes with TGF‑β signaling by reducing SMAD_2/3 activation and nuclear import, highlighting its utility for studying TNIK‑ and Wnt‑dependent oncogenic pathways.

References : Masuda M. et al.: Nat. Commun., 7, 12586, 2016; Sugano T. et al.: Br. J. Cancer, 124(1), 228-236, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.