Neflamapimod

SI-6361

Neflamapimod, >98% (HPLC)

CAS No. : [209410-46-8]

Synonyms : VX-745

IUPAC Name : 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Neflamapimod selectively inhibits p38α with low‑nanomolar potency and shows substantially reduced activity toward p38β. Its strong CNS penetration and anti‑inflammatory profile make it a valuable tool for studying p38α‑dependent inflammatory and neurodegenerative mechanisms.

References : Duffy J. P. et al.: ACS Med. Chem. Lett., 2(10), 758-63, 2011; Cicenas J. et al.: Cancers, 10(1), 2017; Pradal J. et al.: Eur. J. Pharm. Biopharm. 93, 110-7, 2015; Alam J. J. et al.: J. Alzheimers Dis., 48(1), 219-27, 2015; Bagley M. C. et al.: Bioorg. Med. Chem. Lett., 17(18), 5107-10, 2007; Hideshima T. et al.: Blood, 101(2), 703-705, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.