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Nelonicline

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SI-5667

Nelonicline, >98% (HPLC)

CAS No. : [1026134-63-3]

Synonyms : ABT-126

IUPAC Name : 2-(((1r,3R,4r,5S,7s)-1-Azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole

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Chemical Properites
Mol. Formula :
C17H19N3OS
Mol. Weight :
313.42
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Nelonicline is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). It is used for the research of shizophrenia and Alzheimer's disease.

References : Zhang D. et al.: Mov Disord 30(14), 1901-1911, 2015; Haig G. et al.: Neuropsychopharmacology 41(12), 2893-2902, 2016; Gault L. M. et al.: Alzheimers Res Ther., 8(1), 44, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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