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Netarsudil dihydrochloride

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SI-5461

Netarsudil dihydrochloride, >98% (HPLC)

CAS No. : [1253952-02-1]

MDL No. : MFCD29472289

Synonyms : AR-13324 dihydrochloride

IUPAC Name : (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dihydrochloride

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Chemical Properites
Mol. Formula :
C28H27N3O3 . 2HCl
Mol. Weight :
526.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Netarsudil dihydrochloride is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.

References : Sturdivant J. M. et al.: Bioorg Med Chem Lett., 26(10), 2475-80, 2016; Li G. et al.: Eur J Pharmacol., 787, 20-31, 2016; Ren R. et al.: Invest Ophthalmol Vis Sci., 57(14), 6197-6209, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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