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Netupitant N-oxide

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Netupitant N-oxide, >98%

CAS No. : [910808-11-6]

Synonyms : Netupitant M2

IUPAC Name : 4-(5-(2-(3,5-Bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methylpiperazine 1-oxide

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Chemical Properites
Mol. Formula :
C30H32F6N4O2
Mol. Weight :
594.60
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Netupitant, which is a highly potent and selective, orally active neurokinin-1 receptor (NK-1) antagonist. This is used to prevent nausea and vomiting that is caused by cancer medicines.

References : Flick C. A et al.: Bioorg. Med. Chem. 24(9), 1937-1980, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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