NIBR-127

SI-7428

NIBR-127, >98% (HPLC)

IUPAC Name : 2-(Naphthalen-2-yloxy)-1-(4-(2-phenylacetyl)piperazin-1-yl)ethan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : NIBR‑127 is a potent, selective GPR183 (EBI2) antagonist developed by Novartis for probing GPR183‑mediated immune regulation. It blocks oxysterol‑driven GPR183 signaling with high specificity and is widely used as a tool compound to study B‑cell positioning, chemotactic responses, and inflammatory disease mechanisms linked to GPR183 activity.

References : Gessier F. et al.: J. Med. Chem., 57(8), 3358-68, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.