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Nicorandil-d4

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SL-3577

Nicorandil-d4, >98% (CP)

Isotopic Purity : 98 atom % D

CAS No. : [1132681-23-2]

Synonyms : 2-(Nicotinamido)ethyl nitrate-d4; SG-75-d4

IUPAC Name : 2-(nicotinamido-d4)ethyl nitrate

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Chemical Properites
Mol. Formula :
C8H5D4N3O4
Mol. Weight :
215.20
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Nicorandil-d4 is a deuterium labelled version of Nicorandil, which is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP), used to treat angina.

References : Sato T. et al. J. Am. Coll. Cardiol., 35(2), 514-518, 2000; Akao M.et al.: J. Am. Coll. Cardiol., 40(4), 803-810, 2002; Szczepanik A. M. et al.: J. Pharmacol Exp Ther., 278(2), 913-920, 1996; Teshima Y. et al.: Brain Res., 990(1-2), 45-50, 2003; Sathish V. et al.: Mol Cell Biochem., 243(1-2), 133-138, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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