Niflumic acid methyl ester

SL-11135

Niflumic acid methyl ester, >98%

CAS No. : [59361-45-4]

Synonyms : Niflumic acid EP impurity F

IUPAC Name : Methyl 2-((3-(trifluoromethyl)phenyl)amino)nicotinate

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Applications : This is an impurity of Niflumic acid, which acts as both a calcium-activated chloride channel blocker and a COX-2 inhibitor. It induces apoptosis in lung cancer cells through the caspase-8/Bid/Bax pathway. Niflumic acid also shows anti-tumor effects by regulating ERK1/2 expression and affecting MMP2 and MMP9 activity. Niflumic acid is used to treat rheumatoid arthritis.

References : Criddle D. N.: et al., Br. J. Pharmacol., 120(5), 813-8, 1997; Jabeen, T. et al.: Acta Crystallogr. D. Biol Crystallogr., 61(Pt 12), 1579-86, 2005; Picollo A. et al.: J. Membr Biol., 216(2-3), 73-82, 2007; Yuliya V. K. et al.: J. Membr Biol., 247(7), 627-38, 2014; Byeong Mo K. et al.: Cancer Lett., 300(2), 134-44, 2011; Shengqun L. et al.: Int. J. Clin Exp Pathol., 8(9), 9990-10001, 2015; Florentin I. et al.: Int. J. Immunopharmacol., 11(2), 173-83, 1989; Mitsuko K. et al.: Allergol Int., 61(1), 133-42, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.