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Nifuratel

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Nifuratel, >98%

CAS No. : [4936-47-4]

IUPAC Name : (E)-5-((Methylthio)methyl)-3-(((5-nitrofuran-2-yl)methylene)amino)oxazolidin-2-one

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Chemical Properites
Mol. Formula :
C10H11N3O5S
Mol. Weight :
285.27
Appearance :
Yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Nifuratel is an orally active, broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer, and anti-inflammatory properties. It effectively inhibits Candida, Trichomonas, and human gastric cancer cell growth, induces apoptosis, and acts as a STAT3 inhibitor. Nifuratel also suppresses mast cell-mediated hypersensitivity, making it useful for studying IgE-mediated allergic diseases.

References : Polatti F. Curr Clin Pharmacol., 7(1), 36-40, 2012; Nijevitch A. A. et al.: Aliment Pharmacol Ther., 22(9), 881-7, 2005; Nijevitch A. A. et al.: Helicobacter., 12(2), 132-5, 2007; Xie T. et al.: Microbiology Spectrum., 11(5), e05147-22, 2023; Zheng H. et al.: Cancer management and research, 565-572, 2017; Lee J. E. et al.: Int. J. Immunopathol. Pharmacol., 37, 03946320231202349, 2023; Mendling W. et al.: Arzneimittelforschung 52(01), 8-13, 2002; Tynan A. P. et al. British Journal of Urology, 41(3), 271-279, 1969.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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