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Ningetinib tosylate

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SI-8055

Ningetinib tosylate, >98% (HPLC)

CAS No. : [1394820-77-9]

IUPAC Name : N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 4-methylbenzenesulfonate

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Chemical Properites
Mol. Formula :
C31H29FN4O5 • C7H8O3S
Mol. Weight :
728.79
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ningetinib tosylate is an orally active multi‑target TKI with strong potency against c‑MET (IC50 = 6.7 nM), VEGFR2 (1.9 nM), and AXL (<1.0 nM). Its coordinated inhibition of these oncogenic pathways makes it valuable for investigating tumor growth, angiogenic signaling, and therapeutic resistance.

References : Xi N. et al.: Cancer Res., 74(19 Suppl), 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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