Nirogacestat

SI-6259

Nirogacestat, >98% (HPLC)

CAS No. : [1290543-63-3]

Synonyms : PF-3084014

IUPAC Name : (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Nirogacestat selectively and reversibly inhibits γ‑secretase with nanomolar potency (IC₅₀ = 6.2 nM). By attenuating Notch signaling while limiting gastrointestinal adverse effects, it supports mechanistic and therapeutic research in Notch‑dependent tumor models.

References : Wei P. et al.: Mol. Cancer Ther., 9(6), 1618-28, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.