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NMS-859

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SI-5776

NMS-859, >98% (HPLC)

CAS No. : [1449236-96-7]

MDL No. : MFCD28963957

IUPAC Name : 2-Chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)methyl)phenyl)acetamide

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Chemical Properites
Mol. Formula :
C16H13ClN2O3S
Mol. Weight :
348.8
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

References : Magnaghi P. et al.: Nat Chem Biol., 9(9), 548-56, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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