NNRT inhibitor

SI-7247

NNRT inhibitor, >98% (HPLC)

IUPAC Name : (E)-4-((9-(4-(2-Cyanovinyl)-2,6-dimethylphenyl)-8-oxo-8,9-dihydro-7H-purin-2-yl)amino)benzonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a bicyclic HIV‑1 NNRTI derived from etravirine/rilpivirine scaffolds, incorporating a modified heterobicyclic core and an acrylonitrile substituent. It shows single‑digit nanomolar potency against WT HIV‑1 (EC₅₀ = 2.5 nM) and retains low‑nanomolar activity against HXB2 and key NNRTI‑resistant strains (K103N, Y181C; fold change 1.2–6.7×). Notably, it exhibits markedly improved aqueous solubility in PBS (10.4 μM, vs. ≪1 μM for ETV/RPV). X‑ray crystallography confirms its binding mode within the NNRTI pocket, supporting its advancement as a next‑generation NNRTI lead.

References : Prener L. et al.: J. Med. Chem., 66(3), 1761-1777, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.