NNRTI inhibitor

SI-6053

NNRTI inhibitor, >98% (HPLC)

CAS No. : [2415256-47-0]

IUPAC Name : (E)-4-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent next‑generation NNRTI that shows superior anti‑HIV‑1 activity to etravirine (ETR) across multiple NNRTI‑resistant HIV‑1 strains. It displays no cross‑resistance with NRTIs, and features improved solubility, lower CYP liability, and reduced hERG inhibition. With strong pharmacokinetics in rats (F = 37.06%) and high safety in mice (LD₅₀ > 2000 mg/kg), 9a stands out as a promising anti‑HIV‑1 drug candidate.

References : Kang D. et al.: J. Med. Chem., 63(9), 4837-4848, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.